Drug interactions may cause your medicines to function differently or put you at risk for severe adverse effects. This list may not include all potential medication interactions. Keep a list of everything you take (including prescription and nonprescription medications, as well as herbal items) and discuss it with your doctor and pharmacist. Without your doctor’s permission, do not begin, stop, or alter the dose of any medications.
Certain pain medicines (mixed opioid agonist-antagonists such as pentazocine, nalbuphine, and butorphanol), as well as naltrexone, may interact with this substance.
When MAO inhibitors are used with this medicine, a severe (potentially deadly) drug interaction may occur. During therapy with this medicine, do not use MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine). Most MAO inhibitors should be avoided for two weeks before starting this therapy. When should you start or stop taking this medication? Consult your doctor.
If you take additional medicines that boost serotonin, you’re more likely to get serotonin syndrome or poisoning. Street drugs like MDMA/”ecstasy,” St. John’s wort, and antidepressants (such as SSRIs like fluoxetine/paroxetine and SNRIs like duloxetine/venlafaxine) are just a few examples. When you first start or raise the dosage of these medications, you may be more susceptible to serotonin syndrome/toxicity.
If someone has overdosed and is experiencing severe symptoms like as passing out or having difficulty breathing, provide naloxone if it is available. Call a poison control centre immediately away if the individual is awake and has no symptoms. Residents in the United States may contact their local poison control centre . Slow breathing, slow/irregular heartbeat, unconsciousness, and seizures are all signs of an overdose.
Overdosage symptoms include the following:
- pupil size is shrinking (the black circle in the centre of the eye)
- breathing problems
- breathing that is shallow or sluggish
- severe tiredness or drowsiness
- unable to react or awaken
- sluggish heartbeat
- muscle wasting
- skin that is cold and clammy
How should tramadol be used?
Tramadol may be taken by mouth as a tablet, a solution (liquid), an extended-release (long-acting) tablet, or an extended-release (long-acting) capsule. The normal pill and solution are typically taken every 4 to 6 hours, with or without meals, as required. Once a day, take the extended-release pill or extended-release capsule. Every day, take the extended-release tablet and extended-release capsule at approximately the same time. You may take the extended-release pill with or without meals if you want. If you’re taking an extended-release pill, you should either take it with meal or without food every time. Tramadol should be taken precisely as prescribed. Do not take more medicine in a single dosage or in more doses per day than your doctor has recommended. Taking more tramadol than your doctor prescribed or in an unapproved manner may result in severe adverse effects or death. If you are using the solution, normal pills, or orally disintegrating tablets, your doctor may start you on a low dosage of tramadol and gradually increase the quantity of medicine you take every 3 days, or every 5 days if you are taking the extended-release tablets or extended-release capsules.